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Computational protein design refers to the implementation of the physical forces and interactions that govern protein behavior into computational algorithms and models, which can then be used to predictably design new proteins with a desired structure and function. In recent years, this has enabled the development of highly stable "miniproteins" which do not exist in nature, capable of targeting tumor antigens. Our ultimate goal is to advance this field translationally, enabling a new paradigm for cancer immunotherapy that is safer and more efficacious than traditional therapies.